منابع مشابه
Ion Channels and Membrane Potential
Cells are demarcated by the cell membrane. The cell membrane is a lipid bilayer in which various protein molecules are embedded (see Figure 1). In all animal cells, there is a large difference in ionic concentration between inside and outside the cell (Table 1). Na concentration is higher outside the cell and the K concentration is higher inside the cell. Intracellular Ca concentration is kept ...
متن کاملCell Membrane and Ion Channels
Contents 1. Introduction 2. Experimental techniques 2.1. Ion concentrations 2.2. Whole-cell recording 2.3. Current clamp and voltage clamp 2.4. Voltage clamp experiments 2.5. Recording single channel activity 2.6. Rundown 2.7. Effect of intracellular calcium buffering 2.8. Heterogeneity of cardiac cells 2.9. Electrical pathway between cells 3. Modeling the cell membrane and ion channels 3.1. El...
متن کاملHow does the heart sense changes in oxygen tension: a role for ion channels?
SIGNIFICANCE Oxygen plays a key role in cellular metabolism and function. Oxygen delivery to cells is crucial, and a lack of oxygen such as that which occurs during myocardial infarction can be lethal. Cells should, therefore, be able to respond to changes in oxygen tension. RECENT ADVANCES Since the first studies examining the acute cellular effect of hypoxia on activation of transmitter rel...
متن کاملHow do membrane proteins sense water stress?
Maintenance of cell turgor is a prerequisite for almost any form of life as it provides a mechanical force for the expansion of the cell envelope. As changes in extracellular osmolality will have similar physicochemical effects on cells from all biological kingdoms, the responses to osmotic stress may be alike in all organisms. The primary response of bacteria to osmotic upshifts involves the a...
متن کاملIon transport through cell membrane channels
We discuss various models of ion transport through cell membrane channels. Recent experimental data shows that sizes of ion channels are compared to those of ions and that only few ions may be simultaneously in any single channel. Theoretical description of ion transport in such channels should therefore take into account interactions between ions and between ions and channel proteins. This is ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2005
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0501640102